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As soon as I began to watch, I knew that Twilight would become princess. I mean Elements of Harmony are necklaces, except for the Element of Magic who is a tiara.
At that moment it was clear that Twilight Sparkle was supposed to be above the other mane 6. And what not with her being the protégé of Princess Celestia herself.
I'm taking a shot in the dark here but pretty sure before the series ends, Twilight Sparkle will eventually surpass her mentor in every way possible and will inherit the Astral Sisters' legacy.
About the CMC, from a story telling standpoint, those 3 must get their cutie marks before the series ends, that's the one thing I'm looking for so far.
One thing that make them interesting is that due to the fact they are still blank flanks, they have much more margin for character development than almost every other characters in the series so far.